研究發(fā)現DMP1蛋白具抗血管生成作用(3)
2011-01-27 10:57
閱讀:4160
來(lái)源:愛(ài)愛(ài)醫編輯部
作者:水**南
責任編輯:水北天南
[導讀] 一個(gè)來(lái)自GIGA-Cancer/Liège大學(xué)醫院的研究隊伍在《血液》剛剛出版的期刊上發(fā)表文章稱(chēng),他們新發(fā)現了牙本質(zhì)基質(zhì)蛋白具有抗血管生成的作用,這在以前沒(méi)有發(fā)現過(guò)
But Doctor Akeila Bellahcène's most recent research demonstrates that DMP1 also deserves very special attention. In effect the results published in the journal Blood show that DMP1 is capable of blocking angiogenesis. Yet angiogenesis is vital for the development of tumours beyond a few cubic millimetres, as well as for the formation of metastases.
The work shows that DMP1 prevents endothelial cells (the cells which form new blood vessels over the course of angiogenesis) to respond to VEGF, a molecular signal sent by cancer cells to activate the formation of new feeder blood vessels. The presence of DMP1 halts the different stages which lead to the formation of new capillaries: the endothelial cells are placed in a resting non proliferative state.
"In an in vivo model of angiogenesis linked to tumour development, we have shown that the tumours from cancer cells in which we had beforehand overexpressed DMP1 had a reduced growth combined with very modest vascularisation in comparison with the control tumours," points out Doctor Bellahcène.
版權聲明:
本站所注明來(lái)源為"愛(ài)愛(ài)醫"的文章,版權歸作者與本站共同所有,非經(jīng)授權不得轉載。
本站所有轉載文章系出于傳遞更多信息之目的,且明確注明來(lái)源和作者,不希望被轉載的媒體或個(gè)人可與我們
聯(lián)系zlzs@120.net,我們將立即進(jìn)行刪除處理