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　　《國際小兒耳鼻咽喉頭頸外科雜志》最新一項針對多種增強鼓膜（TM）穿孔愈合輔助治療療效的研究指出，盡管許多研究展示了有前景的結果，但是仍然有許多問(wèn)題亟待解決。

　　來(lái)自加拿大的研究者針對TM穿孔檢索了PubMed2000年1月至2012年6月之間的文獻，包括引文。納入和排除的標準適用于所有評估輔助療法對TM愈合的實(shí)驗研究。

　　結果發(fā)現，許多研究已經(jīng)評估了生物分子或者生長(cháng)因子，比如表皮生長(cháng)因子和成纖維細胞生長(cháng)因子的療效，在TM再生方面有重大的成功。TM組織工程最近的策略涉及生物工程支架材料，比如絲纖蛋白，殼聚糖和脫細胞的細胞外基質(zhì)。大多數支架材料展示了良好的生物相容性和更快的TM穿孔愈合速率。

　　研究者指出，盡管許多研究展示了有前景的結果，但是仍然有許多問(wèn)題亟待解決，比如動(dòng)物模型的充分性和輔助材料的長(cháng)期生物相容性。同時(shí)，在臨床應用之前需進(jìn)一步對眾多輔助成分和生物支架進(jìn)行對比研究。

　　Repair of tympanic membrane perforation using novel adjuvant therapies: A contemporary review of experimental and tissue engineering studies.

　　Hong P, Bance M, Gratzer PF.

　　SourceIWK Health Centre, Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada; School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada.

　　Abstract

　　OBJECTIVE: To perform a contemporary review of experimental studies to describe the effects of various novel adjuvant therapies in enhancing tympanic membrane (TM) perforation healing.

　　METHODS: A PubMed search for articles from January 2000 to June 2012 related to TM perforation, along with the references of those articles, was performed. Inclusion and exclusion criteria were applied to all experimental studies assessing adjuvant therapies to TM healing.

　　RESULTS: Many studies have assessed the efficacy of biomolecules or growth factors, such as epidermal growth factors and basic fibroblast growth factors, in TM regeneration with significant success. More recent strategies in TM tissue engineering have involved utilizing bioengineered scaffold materials, such as silk fibroin, chitosan, calcium alginate, and decellularized extracellular matrices. Most scaffold materials demonstrated biocompatibility and faster TM perforation healing rates.

　　CONCLUSION: Although several studies have demonstrated promising results, many questions still remain, such as the adequacy of animal models and long-term biocompatibility of adjuvant materials. As well, further studies comparing various adjuvant substances and bioscaffolds are required prior to clinical application.