幻女**毛片,99热精品免费,日韩欧美亚洲精品,国产床上视频,国产成人精品一区二三区,99ri精品,国产区视频

Myelodysplastic syndrome  內容預覽： 

（點(diǎn)擊下圖可對專(zhuān)家課件進(jìn)行全文預覽）

Myelodysplastic syndrome  內容簡(jiǎn)介：

Myelodysplasticsyndromeoverview
RazelleKurzrock
SeminarsinHaematology,Vol39,No3,Suppl2(July)2002,pp18-25

Myelodysplasticsyndrome(MDS)
Itisatermforaheterogeneouscollectionofhaemopoieticstemcelldisordersaffectingolder**s.
Thereisunderlyingineffectivenessofhaemopoiesisthatresultsindysplasiaofbonemarrowprecursorsandpe**heralcytopenias.

ModerateanaemiaisthemostcommonclinicalprobleminMDSpatients,butcompletemyeloidbonemarrowfailurealsooccursleadingtodeathfrombleedingorinfection.
ApproximatelyhalfofthepatientstransformtoAML.

Prognosisdependsontheindividual’sriskfactors,withmediansurvivalrangingfrom5.7yearsinlower-riskgroupto1.2yearsorlessinthosewithhigher-riskMDS.
MDSisextremelydifficulttotreat.Mostcasesareresistanttocurrenttherapies,andthemostpotentanti-MDStreatments(transplantationanddoseintensivechemotherapy)areoftentootoxicforthemajorityofpatients.

MDSbackground
Pathobiology
ThecardinalfeaturesofMDSare
Increasedmarrowproliferation
Failureofstemcellstodifferentiate
Andincreasedmarrowapoptosis.
Thediseaseisofclonalorigin
Chromosomalabnormalitiesaredetectablein30-70%ofpatients.Theno.ofchromosomalabn.maycorrelatewiththeriskofprogressiontoAML.

FABclassification
In1982TheFABgroupclassifiedMDSaccordingtoMorphologyandthe%ofmyeloblastsintheBMandPB.
Theseincluded
Refractoryanaemia(RA)
Refractoryanaemiawithringedsideroblasts(RARS)
Refractoryanaemiawithexcessblastinmarrow(RAEB)
CMML
Refractoryanaemiawithexcessblastintransformation
(RAEB-t)

WHOclassification
TheWHOproposedchangesincludingreclassificationofRAEB-ttoAMLandaddingasubgroupcalledrefractorycytopeniaswithdysplasia(RCD)

InternationalPrognosticScoringSystem(IPSS)
ThemostpracticalandvalidatedMDSclassificationsystemcurrentlyavailabletocliniciansistheIPSSwhichpredictsbothsurvivalandriskoftransformationtoAMLbasedon:
Marrowblast%
Cytogenetics
Andnumberofcytopenias.

Myelodysplastic syndrome  ***下載